The VSN method was proposed prior to the advent of Illumina Sentrix BeadChip arrays. This platform offers a statistically large number of within-array replicates that can be utilized for variance stabilization. Lin et al. [12] utilized such replicates to estimate the parameters of the model suggested by Rocke and Durbin. The proposed method, named VST, uses the same transformation as VSN. The difference between these two methods is that they use different ways to estimate the model parameters [12].