1. Introduction Microarray technology has been widely used for various fields such as medical science and basic biology. These methods allow the analysis of exhaustive gene expression changes in specimens which were carried out for their genome analysis. Over the last decade, the number of studies using DNA microarray has rapidly increased, and a PubMed search for “DNA microarray” reveals more than 80,000 publications in May 2015. In particular, many studies using this technology are in the field of oncology, and these studies have identified a number of critical genes in cancer progression. In this review, we provide an overview of the development of principle microarrays and the application of each array, and we introduce initial findings using the combination array. The last section describes the application, limitations, association with next-generation sequencing, and future prospects.