PMC:4996398 / 49382-50269 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4996398","sourcedb":"PMC","sourceid":"4996398","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4996398","text":"4.2.3. Cardiac\nCardiac tissue engineering may involve the regeneration of myocardial tissue by first immobilizing stem cells in a scaffold or matrix in vitro and then placing such a scaffold on, or within, the damaged cardiac tissue. Immobilizing myocardial stem cells within a scaffold ensures that they will remain within the cardiac tissue after implantation. Ceccaldi et al. [138] has studied the influence of alginate composition on mesenchymal stem cells in alginate scaffolds. Their conclusion was the G-rich alginate hydrogels provided the most appropriate milieu for MSCs intended for cardiac therapy. Levit et al. [139] have shown similar results where alginate-encapsulated human mesenchymal stem cells were placed onto a rat heart as a hydrogel patch. The alginate hydrogel retained the MSCs and led to an improvement of cardiac function following induced myocardial infarct.","divisions":[{"label":"Title","span":{"begin":0,"end":14}}],"tracks":[{"project":"2_test","denotations":[{"id":"27600217-22776769-69475982","span":{"begin":380,"end":383},"obj":"22776769"},{"id":"27600217-24113327-69475983","span":{"begin":625,"end":628},"obj":"24113327"}],"attributes":[{"subj":"27600217-22776769-69475982","pred":"source","obj":"2_test"},{"subj":"27600217-24113327-69475983","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#afec93","default":true}]}]}}