Figure 1  Schematic overview of TMA donor blocks. (A) TMA performed by TMA-M (core diameter is 1 mm, and distance between cores is 0.5 mm). (B) TMA performed by TMA-GM (core diameter is 1 mm, and distance between cores is 0.7 mm). (C) TMA performed by old machine (core diameter is 0.6 mm, and distance between cores is 0.6 mm). (D) TMA performed with TMA-GM (core diameter is 0.6 mm, and distance between cores is 0.6 mm). Red and Green circles represent the selected tissues in each TMA donor block to be re-punched and transferred to a new recipient block. (For donor TMAs with 1mm diameter tissues, red circles represent tissues punched with TMA-M (A), and green circles represent tissues punched with TMA-GM (B). For donor TMAs with 0.6 mm diameter tissues, red circles represent tissues punched with original TMA instrument (C), and green circles represent tissues punched with TMA-GM (D).