Figure 3  Split-APT gold nanoparticles interacting modes with the aptamer microarray: (A) Split-APT gold nanoparticles do not interact with APT8 spots due to the folding of the complete aptamer; (B) Split-APT gold nanoparticles interacts with Split-APT8 spots through hybridization even without adenosine; (C) Split-APT gold nanoparticles do not interact with Split-APT4 spots without adenosine, but (D) interacts with Split-APT4 spots in presence of adenosine.