PMC:4996384 / 12935-13659 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4996384","sourcedb":"PMC","sourceid":"4996384","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4996384","text":"Figure 1 Reflectivity shifts observed upon injection of gold nanoparticles grafted with Split-APT sequences on various spots of the Surface Plasmon Resonance imaging (SPRi) biosensor surface without the target adenosine present in the solution. Signal increase is observed only on Split-APT8 spots through hybridization of the hairpin stems of the split‑aptamers. APT8 and APT4 spots do not present signal shift due to a folding of the complete aptamer on the surface while Split-APT4 sequences present stems (four bases) too short to hybridize with the Split-APT sequences grafted on the gold nanoparticles. Lack of non-specific signal is also confirmed on control spots with sequences CN8 and Split-APT or on pure gold. ","tracks":[]}