Identified potential effector mechanisms followed by anti-CD20 mAbs. (1) CDC – Complement dependent cytotoxicity. (2) ADCC – Antibody dependent cellular cytotoxicity. (3) PCD – Programmed cell death. (4) ADCP – Antibody dependent cellular phagocytosis. (5) ROS dependent non-apoptotic cell death. (6) Homotypic adhesion and Lysosome mediated non-apoptotic cell death.