Moreover, the subtypes of a disease should be taken into consideration when you choose patients as the participants in neuroimaging study for the patients with different subtypes might have functional or/and structural differences in brain. For example, schizophrenic subjects with predominantly negative symptoms have greater metabolic abnormalities than subjects with predominantly positive symptoms [181]. So, in acupuncture-neuroimaging study, it is better to choose the same subtype of a disease to ensure the homogeneity of participants.