PMC:4731516 / 20745-21254
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4731516","sourcedb":"PMC","sourceid":"4731516","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4731516","text":"Hypothesis: Alpha-synuclein loss-of-function as a contributor to parkinsonian pathology. Our findings suggest that the region-specific degeneration of ventral midbrain dopamine neurons characteristic of Parkinson's disease that is widely attributed to accumulation of toxic aggregates of alpha-synuclein can be accurately reproduced by knockdown of endogenous alpha-synuclein. These differing paths to degeneration converge upon displacement of alpha-synuclein from its natural location at synaptic terminals.","tracks":[]}