In summary, 14-day caloric/fat restriction attenuated MSNA and pressor responses during isometric exercise to fatigue but not to post-exercise muscle ischemia. This indicates that the integrity of the metaboreflex is maintained whereas the influence of the mechanoreflex and/or central command may be reduced. Similar increases in MSNA, HR, and BP during the cold pressor test were recorded following each intervention indicating that central reflex activation may remain intact. We conclude that hypocaloric low-fat intake reduces the pressor response to static exercise. Further research will be required to (1) more clearly elucidate which portion(s) of the reflexes are impaired following caloric restriction and (2) determine the underlying metabolic/hormonal signals associated with the observed neural and cardiovascular changes.