By employing various stressors, it is possible to characterize afferent and efferent reflex pathways and determine how environmental adaptations (e.g., spaceflight, bedrest, fasting) modulate neural and cardiovascular responses. Static handgrip to fatigue elicits increases in blood pressure (BP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) [10]. The primary mechanisms responsible for the neural and cardiovascular responses are activation of central command, a feedforward control mechanism via stimulation of the cardiovascular center from descending central neural pathways, and the exercise pressor reflex, a feedback control mechanism emanating from mechano- and metaboreceptors in skeletal muscles [10, 11]. Reflex pathways originating from cold nociceptors in the skin and involving central vasomotor centers can be assessed by sympathetic and pressure responses to the cold pressor test [9, 12].