Previous studies examining reflex neural control of the cardiovascular system following spaceflight or bedrest have reported impaired [2, 4–6, 8] or intact [9, 23] functional responses to cold pressor and/or static handgrip exercise. Therefore, the current study was conducted to determine the effects of hypocaloric intake, similar to that during spaceflight [13], on neural and cardiovascular control. We hypothesized that caloric/fat restriction alone would alter physiological responses, and that these changes would be exacerbated when caloric restriction was combined with bedrest; however, our findings support only the first part of our hypothesis.