Fig. 2 Systemic neural and hemodynamic responses to static handgrip and post-exercise muscle ischemia. Data are presented as mean ± SEM. The x-axis during exercise corresponds to the % of time to fatigue. C1 and C2, minutes 1 and 2 of arm cuff occlusion. MSNA is adjusted to minute values and expressed as bursts/min. The main effects calorie, posture, and time are significantly different for HR. Following caloric restriction, the responses of all variables during exercise are attenuated (calorie * time interaction). Values during 2 min of occlusion are similar