PMC:4719559 / 14742-16698 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4719559","sourcedb":"PMC","sourceid":"4719559","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4719559","text":"Cardiovascular response to handgrip\nThe time to fatigue during static handgrip was similar following all four interventions (p \u003e 0.05). Hemodynamic measurements before, during, and after handgrip and post-exercise circulatory arrest are presented in Fig. 2. Heart rate was significantly lower at baseline and throughout the protocol following caloric restriction, whereas bedrest was associated with a higher HR. At the same relative forces, HR gradually increased during static handgrip, reached its peak at fatigue, and immediately returned to baseline values during post-exercise circulatory arrest following each intervention. The contraction-induced increases in HR were diminished with caloric restriction (calorie * time interaction p \u003c 0.001). Systolic and diastolic BP (SBP and DBP) increased progressively during static handgrip, peaked at fatigue, and decreased but remained elevated compared to baseline during post-handgrip circulatory arrest. The increase in DBP (Fig. 2) and SBP (Figs. 2 and 3) during handgrip were greatly attenuated with caloric restriction independent of bedrest. Responses were well maintained during post-exercise ischemia.\nFig. 2 Systemic neural and hemodynamic responses to static handgrip and post-exercise muscle ischemia. Data are presented as mean ± SEM. The x-axis during exercise corresponds to the % of time to fatigue. C1 and C2, minutes 1 and 2 of arm cuff occlusion. MSNA is adjusted to minute values and expressed as bursts/min. The main effects calorie, posture, and time are significantly different for HR. Following caloric restriction, the responses of all variables during exercise are attenuated (calorie * time interaction). Values during 2 min of occlusion are similar\nFig. 3 The change in SBP at the point of maximum fatigue. Data are presented as mean ± SEM. The maximum SBP response to static handgrip to fatigue was significantly attenuated following caloric restriction, independent of bedrest","divisions":[{"label":"title","span":{"begin":0,"end":35}},{"label":"figure","span":{"begin":1161,"end":1726}},{"label":"label","span":{"begin":1161,"end":1167}},{"label":"caption","span":{"begin":1168,"end":1726}},{"label":"p","span":{"begin":1168,"end":1726}},{"label":"label","span":{"begin":1727,"end":1733}}],"tracks":[]}