Va is a vector including levels of all the markers in the mini network in pathogenic state. Vb is a vector including levels of all the markers in the mini network in normal state. |Va| and |Vb| are their modular. The symbol “T” in Equation (3) represents vector transposition. Moreover, a simulation experiment is performed for investigating the physiological significance of the disruption parameters (shown in Investigation of Disruption Parameters Physiological Significance).