Estimation of mini network integral disruption parameters
In this study, three mini network integral disruption parameters U, K, and φ are used to evaluate the integral variation of the mini network.
(1)  K = | V a   |   | V b   |          (2)  φ = cos  − 1   V a  · V b   | V a   |  | V b   |          (3)  U = ( V  a   - V  b    )  ( V  a   - V  b    )   T          Va is a vector including levels of all the markers in the mini network in pathogenic state. Vb is a vector including levels of all the markers in the mini network in normal state. |Va| and |Vb| are their modular. The symbol “T” in Equation (3) represents vector transposition. Moreover, a simulation experiment is performed for investigating the physiological significance of the disruption parameters (shown in Investigation of Disruption Parameters Physiological Significance).