In this study, the longitudinal biomarker data (4 years, version: 2012-09-06) in ADNI-1 is used to develop the model. The data set includes three CSF markers: Tau protein, Aβ, and Phosphorylated tau protein (P-tau). Details of the CSF analysis and quality control measures have previously been published (Shaw et al., 2009). The patients are divided into three groups: AD, MCI, and normal control group. The CSF samples are collected at four time points: 12, 24, 36, and 48 months. Patients with missing data are excluded in our experiments. The demographic information of subjects used in this study at different time points is given in Table 1.