In this study, a cross-talk network is established by integrating the interactions among CSF biomarkers. As a complex biology system, cross-talk network has two properties. The first is small-worldness which means that most pairs of nodes can be linked to each other by relatively short chains (Maslov and Ispolatov, 2007; Zhao et al., 2010). Secondly, robustness is the capacity of keeping homeostasis under a range of condition which may be disrupted by disease (He et al., 2013; Nijhout and Reed, 2014).