The boxplot of mini network disruption parameters (Figure 7A) shows that these three parameters in both AD and MCI groups are significantly greater than those in normal group (P < 0.01, based on One-way ANOVA, Table 3) which suggests that if mini network disruption parameters U, K, and φ are higher than the upper whisker of normal group, the patient may have high disease risk. Moreover, the trajectory figure (Figure 7B) shows that the variation of parameter U is similar to the disease progression.