Table 2 The mini network integral disruption parameters changes in simulation experiment. Gradient (%) K (%) φ (%) U (%) Situation: single marker simulation 10 3.78 12.88 11.09 20 7.77 25.07 23.45 50 20.77 57.21 65.17 Situation: multi-markers simulation 1 10 10.00 0.00 0.27 20 20.00 0.00 6.82 50 50.00 0.00 57.85 Situation: multi-markers simulation 2 10 2.19 27.68 25.30 20 3.38 57.21 51.38 50 0.82 147.97 131.69