The simulation experiment result is presented in the Table 2. The results of single marker changing simulation indicate that the parameters U and φ are related to the variation of single marker. The results of multi-marker changing simulation 1 suggest that parameter K is related to the consistency multi-marker changing and U is sensitive to the great consistency variation of multi-marker. The results of multi-marker changing simulation 2 indicate that parameters U and φ are related to the multi-marker inconsistency variation. We summarize physiological significance of U, K, and φ with the simulation experiment evidence. U is responses to both consistency variation and inconsistency variation comprehensively. K responds to multi-marker consistency variation. φ is response to the multi-marker inconsistency variation.