Investigation of disruption parameters physiological significance
To illustrate significance of U, K, and φ, we perform a simulation experiment. The change of biomarkers is simulated in three cases. The three situations are shown as follows: Single marker changing simulation: Only one marker changes as the gradient.
Multi-marker changing simulation 1: All the markers increase as the gradient. For instance, the gradient is 10%. At this situation, all three markers increase 10%.
Multi-marker changing simulation 2: The first marker increases as the gradient and the other two markers decrease as the gradient. For instance, marker A increases 10% and markers B and C decrease 10%.
Finally, observe the change of the three dynamic parameters U, K, and φ.
For a further insight into the significance of mini network integral disruption parameters, an addition test is performed. Three SVMs are trained for evaluating the contribution of mini network integral disruption parameters in the classification: SVM based on K and φ for assessing the contribution of parameter U, SVM based on K and U for assessing the contribution of parameter φ, SVM based on φ and U for assessing the contribution of parameter K. Then observe the performance of these three SVMs.