Unfortunately, a severe imbalance of the distribution of advanced cancers (>4 involved lymph nodes) was noted among those women screened in the first round < age 50 years. Nineteen women with far advanced cancers (>4 involved lymph nodes) were allocated to the screening group versus five in the control group, and more women with prior breast cancer were reported in the screening group (n = 8 versus n = 1) [28, 31, 34–36].