PMC:4667104 / 18531-19746 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4667104","sourcedb":"PMC","sourceid":"4667104","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4667104","text":"Figure 2 GWAS and HLA association results for influenza A serostatus\n(A) Regional association plot of GWAS results. Values of –log10(p) are plotted by their position in the MHC genomic region on chromosome 6. The most significant association was observed for rs140012631 (p = 1.1 × 10−14, OR = 2.01 for the C allele). Accounting for the effect of rs140012631, we observed an independent association at rs9269912 (p = 8.5 × 10−10, OR = 0.57 for the T allele). A further step of forward conditioning left no genome-wide significant signal. The dashed horizontal line indicates the threshold for genome-wide significance (p = 3.57 × 10−9). The annotated dashed vertical lines indicate the positions of the classical HLA genes.\n(B) Effect estimates for amino acid residues at position 96 of HLA-DRβ1 (omnibus p = 2.6 × 10−16). Designated classical HLA alleles contain the respective amino acid residue at the given position. OR, odds ratio; CI, confidence interval.\n(C) Association results and conditional regression for classical HLA alleles. Conditioning on HLA-DQB1∗05:01 did not reveal further independent associations (threshold: p = 3.57 × 10−9). PC, principal component; OR, odds ratio; CI, confidence interval.","divisions":[{"label":"label","span":{"begin":0,"end":8}},{"label":"p","span":{"begin":10,"end":69}},{"label":"p","span":{"begin":70,"end":724}},{"label":"p","span":{"begin":725,"end":962}}],"tracks":[]}