PMC:4667104 / 1257-1753 JSONTXT

{"project":"2_test","denotations":[{"id":"26456283-4204534-2044877","span":{"begin":208,"end":209},"obj":"4204534"},{"id":"26456283-24725414-2044878","span":{"begin":312,"end":313},"obj":"24725414"},{"id":"26456283-21996708-2044879","span":{"begin":315,"end":316},"obj":"21996708"},{"id":"26456283-4204534-2044880","span":{"begin":371,"end":372},"obj":"4204534"},{"id":"26456283-21996708-2044881","span":{"begin":374,"end":375},"obj":"21996708"}],"text":"The humoral immune response plays an essential role in the control and prevention of viral infections in humans. It has long been known that concentrations of serum immunoglobulins vary from person to person,1 and antibody titers against prevalent viruses have been shown to be highly variable in the population.2, 3 A significant fraction of that variation is heritable,1, 3 yet little is known about the human genetic control and regulation of the immunoglobulin response to specific pathogens."}