PMC:4667104 / 11846-12523 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4667104","sourcedb":"PMC","sourceid":"4667104","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4667104","text":"We also observed significant SNP associations in the HLA class II region for JCPyV and MCPyV serostatus and for MCPyV IgG levels (Table 2, Figures S5A, S6A, and S7). HLA-DRβ1 positions 133 and 13 showed the strongest amino acid associations with JCPyV and MCPyV serostatus, respectively (Figures S5B and S6B), whereas HLA-DQA1∗01:02 and HLA-DQB1∗06:02 were associated with JCPyV and MCPyV seronegativity, respectively (Figures S5C and S6C). These two alleles are in strong LD with HLA-DRB1∗15:01 (Table S7), which was found to be associated with JCPyV seronegativity previously.30 No classical HLA alleles or amino acids reached the significance threshold for MCPyV IgG levels.","tracks":[{"project":"2_test","denotations":[{"id":"26456283-24763718-2044909","span":{"begin":578,"end":580},"obj":"24763718"}],"attributes":[{"subj":"26456283-24763718-2044909","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93e3","default":true}]}]}}