The career described in this paper is the culmination of many collaborations with mentors, colleagues and trainees from numerous laboratories in government, academia, and industry, all of whom I owe a debt of gratitude. I am especially thankful to mentoring I received from Drs. Jim Bosco, John Greenleaf, Ed Bernauer, Hal Sandler, Jack Wilmore, and Joan Vernikos, and the loving support of my wife Barbara.