Golgi structure in mammalian cells is maintained by the cytoskeleton, and GRASPs and golgins (Figure 1A). GRASP65 and GRASP55 form homo- or hetero-oligomers and mediate stacking and can contribute to the Golgi ribbon structure (Ramirez and Lowe, 2009; Xiang and Wang, 2010). The golgin family comprises a group of peripheral Golgi membrane proteins with long coiled coil domains. Some golgins are vesicle tethers, some function in Golgi stack structure, and others may be involved in trafficking of specific cargo molecules (Munro, 2011). Disassembly of the Golgi in mitosis or apoptosis results from reversible phosphorylation of GRASPs and golgins or irreversible cleavage, respectively.