Outlook
Elucidation of the types of stresses that originate at the Golgi complex as well as the resulting signaling pathways will be required for a complete understanding of the role of this important organelle in neurodegeneration as well as other diseases. The identification of transcription factors that respond to Golgi stress, such as TFE3 and CREB3, will greatly aid the dissection of the signaling pathways. Determining how perturbation of Golgi structure and cleavage fragments of Golgi structural proteins influence gene expression is crucial. Finally, the consequences of Golgi fragmentation on cell homeostasis, including membrane traffic, need to be assessed for each type of Golgi stress uncovered.

Conflict of interest statement
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.