Table 1 Chemical properties of tetracycline hydrochloride Molecule Formula Molecular weight (g/mol) Solubility (mol/L) pKa1 pKa2 pKa3 TC C22H24O8N2.HCl 480.9 0.041 3.2 ± 0.3 7.78 ± 0.05 9.6 ± 0.3