Usually, sonochemical treatment lead to degradation of structure and ultimately mineralization of organic compounds [67]. While perfect mineralization for most antibiotics are difficult because of the structural stability [68]. Therefore, the changes of TOC and COD were evaluated during US/S2O82− process and the result are shown in Fig. 9. After 120 min of reaction, TC, COD and TOC were removed approximate 95 %, 73 % and 60 %. The incomplete mineralization implies the potential formation of intermediate products and further identification of the degradation by-products is required. Fig 8 Arrhenius equation graph representation the temperature dependence on chemical reaction rate