Interestingly, in a study by Markowitz and colleagues, extravasated 125I-BSA or Evans blue was noted in the dura of saline-perfused rats following intravenous capsaicin or following electrical stimulation of the rat TG. Extravasation was however not observed in the brain following chemical, electrical, or immunological stimulation nor following topical application of capsaicin to the pial surface or injection into the cortex of rats. The data are therefore showing similar indication as us, with our inflammatory model [39]. As we did not observe any alteration in the BBB, we add our data to the negative experiments that the BBB does not change its permeability during migraine attacks. Our results are in agreement with clinical data observations [26–28].