Control CFA 2 h CFA 24 h CFA 48 h IS 2 h IS 24 h Cortex (μL/mg) 7.3 + 0.6 12.2 ± 2.5 12.6 ± 0.8* 14.6 + 3.0* 11.3 ± 0.7* 11.0 ± 2.0 PAG (μL/mg) 6.0 ± 0.6 15.3 ± 3.2* 12.8 ± 1.4* 8.8 ± 1.5 13.8 ± 2.9 11.8 ± 2.3 Cerebellum (μL/mg) 9.5 ± 0.4 14.2 ± 0.8* 12.8 ± 0.5 29.4 ± 6.2 * 13.8 ± 1.7 16.3 ± 1.3* L Spinal Trigeminal nucleus (μL/mg) 10.3 ± 1.7 14.3 ± 2.3 21.2 ± 2.1* 44.0 ± 14.4* 12.5 ± 3.5* 27.0 ± 8.9 R Spinal Trigeminal nucleus (μL/mg) 12.8 ± 2.6 13.7 ± 1.6 19.4 ± 1.8 23.6 ± 3.4* 16.0 ± 1.8 28.0 ± 11.0 L Trigeminal Ganglion (μL/mg) 52.3 ± 4.3 53.3 ± 12.5 48.0 ± 8.0 25.8 ± 3.1 40.5 ± 13.4 59.3 ± 10.3 R Trigeminal Ganglion (μL/min/g) 54.5 ± 5.7 51.7 ± 10.4 68.2 ± 13.9 22.0 ± 2.6 56.7 ± 15.5 83.8 ± 27.4