Table 2 Plasma volume in tissue in analyzed brain structures. Plasma volume in analyzed structures following application of CFA or IS to the dura was compared to plasma volume in analyzed structure following application of vehicle
Control CFA 2 h CFA 24 h CFA 48 h IS 2 h IS 24 h
Cortex (μL/mg) 7.3 + 0.6 12.2 ± 2.5 12.6 ± 0.8* 14.6 + 3.0* 11.3 ± 0.7* 11.0 ± 2.0
PAG (μL/mg) 6.0 ± 0.6 15.3 ± 3.2* 12.8 ± 1.4* 8.8 ± 1.5 13.8 ± 2.9 11.8 ± 2.3
Cerebellum (μL/mg) 9.5 ± 0.4 14.2 ± 0.8* 12.8 ± 0.5 29.4 ± 6.2 * 13.8 ± 1.7 16.3 ± 1.3*
L Spinal Trigeminal nucleus (μL/mg) 10.3 ± 1.7 14.3 ± 2.3 21.2 ± 2.1* 44.0 ± 14.4* 12.5 ± 3.5* 27.0 ± 8.9
R Spinal Trigeminal nucleus (μL/mg) 12.8 ± 2.6 13.7 ± 1.6 19.4 ± 1.8 23.6 ± 3.4* 16.0 ± 1.8 28.0 ± 11.0
L Trigeminal Ganglion (μL/mg) 52.3 ± 4.3 53.3 ± 12.5 48.0 ± 8.0 25.8 ± 3.1 40.5 ± 13.4 59.3 ± 10.3
R Trigeminal Ganglion (μL/min/g) 54.5 ± 5.7 51.7 ± 10.4 68.2 ± 13.9 22.0 ± 2.6 56.7 ± 15.5 83.8 ± 27.4
Differences in plasma volumes in tissue was found following application of both CFA and IS compared to vehicle (*p < 0.05)