Physiological data
The physiological parameters were examined after 2, 24 and 48 h for CFA, and at 2 and 24 h for IS (Table 1). No significant differences regarding measured physiological data (Na+, K+, pH, pCO2, pO2 and MAP) were observed between the groups.
Table 1 Physiological parameters in animals where Ki for 51Cr-EDTA was determined. Hematocrit in animals treated with CFA was lower than in the vehicle group at 24 h following application to the dura. No other differences regarding measured physiological data were observed between the groups
Vehicle (n = 6) CFA 2 h (n = 6) CFA 24 h (n = 5) CFA 48 h (n = 5) IS 2 h (n = 6) IS 24 h (n = 4)
MAP (mmHg) 98 ± 7 88 ± 3 87 ± 6 105 ± 7 85 ± 5 104 ± 9
Hct (%) 50 ± 2 46 ± 3 38 ± 2* 42 ± 1 46 ± 2 42 ± 2
pCO2 (kPa) 4.6 ± 0.1 4.6 ± 0.1 4.7 ± 0.2 4.5 ± 0.1 4.6 ± 0.1 4.8 ± 0.2
pO2 (kPa) 11.5 ± 0.1 11.6 ± 0.1 11.0 ± 0.2 12.7 ± 0.5 11.4 ± 0.3 11.4 ± 0.5
Na+ (mmol) 136.3 ± 0.6 138.0 ± 1.6 138.6 ± 1.0 137.0 ± 0.5 137.0 ± 0.5 136.5 ± 0.9
K+(mmol) 4.82 ± 0.39 4.65 ± 0.39 4.36 ± 0.13 4.40 ± 0.13 4.57 ± 0.14 4.55 ± 0.22
pH 7.50 ± 0.02 7.45 ± 0.02 7.46 ± 0.02 7.46 ± 0.01 7.48 ± 0.01 7.48 ± 0.01
Differences in plasma volumes in tissue was found following application of both CFA and IS compared to vehicle (*p < 0.05)