Our work benefited significantly from the statistical computational language and environment R, its many packages, and the great support of the R community. All the plots were created in R with the base graphics library. Special thanks are due to Helios de Rosario for his help in technical details of using the R package phia. The research and writing of the paper were supported by the NIMH and NINDS Intramural Research Programs of the NIH/HHS, USA.