Figure 19  Representative MRI image of brain of EC-Mut Tg, EC-WT Tg, SMC-Mut Tg, KO, and WT mice with hypoxia. MRA (upper panel) represents MRA images. No stenotic lesions and moyamoya vessels were detected in brain. T2 (lower panel) represents T2-weighted images. No infarction was detected in brains. Absence of stenotic lesion, moyamoya vessel, and infarction was also confirmed in other 2 mice in each genotype. EC indicates endothelial cell; KO, knockout; MRA, magnetic resonance angiography; MRI, magnetic resonance imaging; SMC, smooth muscle cells; Tg, transgenic; WT, wild type.