The overall prevalence of liver disease in males was 34.3% in homozygotes and 24.4% in compound heterozygotes (p = 0.279), and in females the prevalence was 29% for both genotypes. The rate of liver biopsy was also significantly different between homozygotes and compound heterozygotes for males (10.9% versus 1.8%; p = 0.013) and females (9.1% versus 2%; p = 0.035). No significant genotype differences were found for other liver phenotypes, which included the presence of any liver disease, liver cirrhosis, other chronic liver diseases, hepatocellular carcinoma, elevated transaminases, or physical findings consistent with liver disease (e.g., hepatomegaly or ascites).