We obtained trait-associated SNPs from the GWAS Catalog25 on November 5, 2013. We included only high-frequency (MAF > 5%) bi-allelic autosomal SNPs with a genome-wide significant (p < 5 × 10−8) association with any trait. We included only studies where Europeans contributed to the majority of the final samples to simplify LD calculations. We conducted LD calculations across the selected SNPs by using 379 EUR samples from the 1000 Genomes Project21 and only bi-allelic SNPs with at least five copies of the minor allele. We ensured that these SNPs were independent by randomly excluding one SNP for each pair of SNPs if r2 > 0.1 or if the distance between the SNPs was <100 kb. Finally, we excluded phenotypes with fewer than ten independent SNP associations after our filtering criteria. This resulted in 1,416 SNPs in our test set.