Figure 4  Phenotype-SNP Network
For constructing this network, individual HPO terms were connected to SNPs if the SNP was significantly associated with a disease characterized by the HPO term in question. For instance, the SNP rs5029939 is significantly associated with both Sjögren syndrome51 and systemic lupus erythematosus.52 The diseases also share a number of phenotypic features, including “antinuclear antibody positivity” (HP: 0003493) and “xerostomia” (HP: 0000217). A small and particularly dense subset of the network was manually chosen. The network is centered on ten HPO terms representing clinical features that are common in autoimmune diseases.