This work was supported by the Bundesministerium für Bildung und Forschung (project 0313911), the European Commission Seventh Framework Programme (FP7; grant 602300; SYBIL project), the Raine Clinician Research Fellowship (20140101), and the National Health and Medical Research Council of Australia (grant APP1055319, which is partnered with FP7 grant 305444). Oregon Health and Science University acknowledges the support of grant 1R24OD011883-01 from the NIH Office of the Director. T.G. was supported by an Australian Research Council Discovery Early Career Researcher Award (DE120100508). D.V. was supported in part by the BioMedBridges project funded by Research Infrastructures of the FP7 (grant 284209). H.P. was supported by European Molecular Biology Laboratory Core Funds. This work was supported by the director, Basic Energy Sciences, Office of Science, US Department of Energy under contract DE-AC02-05CH11231 and NIH contract 1R24OD011883-01. This document was prepared as an account of work sponsored by the US Government. While this document is believed to contain correct information, neither the US Government nor any agency thereof, nor the Regents of the University of California, nor any of their employees makes any warranty, express or implied, or assumes any legal responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed or represents that its use would not infringe privately owned rights. The views and opinions of authors expressed herein do not necessarily state or reflect those of the US Government or any agency thereof or the Regents of the University of California.