The plots depict how much of the variance in the sex- and age-adjusted BMI and height phenotypes (adjusted R2) was explained by the methylation-profile score, the genetic-profile score, an additive model including both scores (methylation + genetic), and an interaction model (methylation × genetic). The methylation score in the LBCs is based on selected probes and effects sizes from the LifeLines DEEP MWAS, and vice versa. The genetic-profile scores are based on results from the GIANT meta-GWAS.