Accession Numbers
The European Genome-phenome Archive (EGA) accession number for the Lothian Birth Cohort methylation data reported in this paper is EGA: EGAS00001000910. The Database of Genotypes and Phenotypes (dbGaP) accession number for the Framingham Heart Study methylation data reported in this paper is dbGaP: phs000724.v2.p9. The NCBI Gene Expression Omnibus (GEO) accession number for the Brisbane Systems Genetic Study methylation data reported in this paper is GEO: GSE56105.

Web Resources
The URLs for data presented herein are as follows:Database of Genotypes and Phenotypes (dbGaP), http://www.ncbi.nlm.nih.gov/gap
European Genome-phenome Archive (EGA), https://www.ebi.ac.uk/ega/home
Gene Expression Omnibus (GEO), http://www.ncbi.nlm.nih.gov/geo/

Supplemental Data
Document S1. Supplemental Acknowledgments, Figures S1–S6 and Tables S1–S5
Document S2. Article plus Supplemental Data This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Supplemental Data include Supplemental Acknowledgments, six figures, and five tables and can be found with this article online at http://dx.doi.org/10.1016/j.ajhg.2015.05.014.