Using two proof-of-principle examples in the single-variant testing setting, where GxE interactions have been shown to exist from previous studies, we demonstrate the power of the JLS method. The first example pertains to a locus that determines glycosylated hemoglobin (HbA1c) levels based on a genome-wide association study (GWAS) of type 1 diabetes (T1D [MIM: 222100]) complications.18 The second pertains to determinants of CF lung disease severity.19 For these examples, the known environmental interactors are not explicitly modeled, but we leverage their existence to identify genetic contributors to HbA1c and CF lung disease.