Table 2  Apical Gene-Set and SLC9A3 Complex Association Analysis with CF Lung Disease Severity as Measured by SaKnorm in the Canadian Gene Modifier Study Discovery Sample and in the French Replication Sample
Location-only Test   Scale-only Test   JLS-Fisher Test
Apical Gene-Set (3,814 SNPs)
Canadian Discovery Sample  0.0876  0.0222  0.0099
French replication sample  0.2058  0.0077  0.0180
SLC9A3 Gene-Based (10 SNPs)
Canadian Discovery Sample  <0.0001  0.0238  0.0001
French replication sample  0.0953  0.0415  0.0286
Apical Gene-Set Excluding SLC9A3 (3,804 SNPs)
Canadian Discovery Sample  0.1319  0.0248  0.0161
French replication sample  0.2139  0.0076  0.0182
SLC9A3 Complex: SLC9A3, SLC9A3R1, SLC9A3R2, and EZR (38 SNPs)
Canadian Discovery Sample  <0.0001  0.0016  <0.0001
French replication sample  0.2390  0.0245  0.0415
Apical Gene-Set Excluding the SLC9A3 Complex (3,776 SNPs)
Canadian Discovery Sample  0.178  0.0329  0.0329
French replication sample  0.2173  0.0099  0.0201
Individual location-only and scale-only tests and the joint location-scale Fisher (JLS-Fisher) test were performed in the full CGS (n = 1,409) and French (n = 1,232) samples using unrelated individuals (see Material and Methods and Results). p values reported were estimated from 10,000 permutation replicates.