SaKnorm24 (normalized, averaged sex-, age-, height-, mortality-adjusted forced expiratory volume in 1 s; FEV1) was used as the lung function measure. Analysis was performed on eight SNPs in three candidate genes previously identified as associated with meconium ileus5 and subsequently studied for association with SaKnorm in a pediatric subsample.19 Individual location-only and scale-only tests, joint location-scale Fisher (JLS-Fisher), joint location-scale minimum-P (JLS-minP), the likelihood ratio test (LRT) of Cao et al.,17 and the distribution test of Aschard et al.16 were performed in the full sample of 1,409 unrelated individuals. For comparison, the location-only test was performed in three CGS pediatric subsamples using different age cutoffs of 16, 18, and 20 years.