Figure 3  Association and Linkage Disequilibrium Information across SLC9A3 in the Canadian Gene Modifier Study Sample
(A) Locus Zoom plot50 displaying the genetic association of 374 imputed SNPs (see Online Methods of Sun et al.5) within ±10 kb of SLC9A3 on chromosome 5. SNP colors indicate the pairwise correlation (r2) with the top SNP, rs11743825 at bp 475463. The three vertical lines encompass the two adjacent binding regions of SLC9A3R1/SLC9A3R2 (left side of the dotted line: bp 476,353–476,778) and EZR (right side of dotted line: bp 476,734–480,024). Both binding regions are bounded within the C terminus of the gene (bp 474,977–482,675).
(B) LD plot indicating pairwise correlation between imputed SNPs for the CGS sample using the “snp.plotter” package.51 LD block colors indicate degree of pairwise LD (r2). The triangles outlined with black lines indicate the SLC9A3R1/R2 and EZR binding regions as described in (A).