PMC:4572492 / 31789-32840 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4572492","sourcedb":"PMC","sourceid":"4572492","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4572492","text":"In conclusion, we have provided a robust joint location-scale (JLS) testing framework for the detection of single-variant, gene-set, or pathway associations involving either main or interaction effects, or both. This methodology applies to analysis of a quantitative trait, regardless of the biological interpretation of the chosen scale of phenotypic measurement. Application of the JLS approach identified the SLC9A3 regulatory complex as an important contributor to CF lung disease, which was completely missed in previous analyses of the same data. The JLS association testing method should be considered for future gene-set, pathway, and whole-genome association scans. Further, JLS should be employed to re-examine datasets previously analyzed via the conventional location-only or scale-only testing approaches, for complex traits or complex secondary phenotypes of Mendelian diseases. The method will help researchers pinpoint susceptibility loci for additional analysis toward the understanding of the genetic architecture of a complex trait.","tracks":[]}