Type 1 Diabetes Complications
Traditional analysis using the individual location-only test did not yield a genome-wide significant association of p < 5 × 10−8 (as previously proposed by Dudbridge and Gusnanto28) between rs1358030 and HbA1c (p = 2.3 × 10−7), whereas the JLS-Fisher method did (p = 4.9 × 10−8). Genome-wide significance was also not achieved by the scale-only test (p = 0.01), the distribution test (p = 1.7 × 10−7, estimated from 108 permutation replicates), the LRT (p = 2.0 × 10−7), or the JLS-minP test (p = 4.6 × 10−7).
Knowing the treatment information, Paterson et al.18 was able to explicitly model this interactor and identified rs1358030 as genome-wide significantly associated with HbA1c levels and interacting with treatment type (p = 3.8 × 10−10 and p = 0.013 for the main and interaction effect, respectively).