JLS Method Evaluation by Simulation
We conducted extensive simulation analyses to evaluate the performance of the proposed JLS-Fisher and JLS-minP tests for single-variant analysis and compared them with the individual location-only and scale-only tests, as well as the distribution test16 and the LRT.17 We also conducted a sensitivity analysis on the various tests, studying the impact of poorly captured genotypes that can be expected from imputed datasets. Simulation details are provided in Appendix A.